Muscle Physiology and Disease

Muscle physiology

Join the Neuromuscular Physiology Home Page of the Neuromuscular Physiology Lab at the University of California and their introduction to muscle physiology.

This link is a demo version from the textbook by R. Martini (Fundamentals in Physiology and Anatomy), and summarises the fundamental principles of skeletal muscle physiology and also anatomy.

For people interested in cutting edge research in skeletal muscle physiology, I recommend searching for publications in the American Journal of Physiology.

Muscle disease: neuromuscular disorders and myopathies

The neuromuscular disease center of the Washington University School of Medicine, St. Louis, Missouri, USA is providing a lot of information about myopathies and neuromuscular disorders with a fascinating differential diagnosis index for myopathic and neuromuscular junction disorders like for example myasthenic syndromes, myopathies, malignant hyperthermia and a differential diagnosis of rhabdomyolysis and myoglobinuria.

The U.S. muscle dystrophy association has a web-page that may be very helpful for patients to obtain information on muscle disease and anesthesia. In addition, this site provides a lot of information for patients suffering from this disease.

Pedsanesthesia has information on the congenital myopathies and anesthesia.

Other useful links: mitochondrial disease and anesthesia (PDF), from the United Mitochondrial Disease Foundation, also great e-medicine paper on myopathies, .

Malignant Hyperthermia

The Malignant Hyperthermia Association of the United States (MHAUS) has a great web-site with a lot of information for professionals and patients and their families regarding malignant hyperthermia. For example, their Healthcare Professionals pages include preparing for and managing a crisis, and they have a patient info center, advice on testing, and much more.

Visit the Malignant Hyperthermia Tutorial located at the Swiss Anaesthesia Server, University of Basel, Switzerland. There you’ll find further links to MH research at the Dep. of Anaesthesia, University of Basel, Switzerland and others.

Here is a link to McLennan’s lab, one of the pioneers in MH research.

Richard Riley has a quick simple MH overview.

The European Malignant Hyperthermia group has its one web-page with further interesting links.

Pseudocholinesterase Deficiency has a nice review by Dr. Daniel Alexander.

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